4J14 bio r 250

crystal structure of Human cytochrome p450

Cytochrome p450: A Brief OverviewEdit

The cytochrome p450 family is a group of enzymes that catalyzes the oxidation of unusual molecules in the body. Most of the time, this occurs with organic molecules thus making them soluble in water. Once soluble in water, the molecule can be flushed out of the body. Most commonly, the oxygen is added in a monooxygenase reaction, which reduces two atoms of dioxygen to one hydroxyl group and one molecule of water. Cytochrome p450's belong to a family of proteins that contain a heme cofactor, making them hemoproteins. These enzymes are extremely diverse and can be found in almost every organism on earth including animals, plants, bacteria, archaea, and even viruses. However, the enzyme has not been found in E. Coli. Over 18,000 different cytochrome p450 proteins have been discovered. Because of the immense diversity, a more focused study on the enzyme cytochrome p450 found specifically in humans will be done throughout the article.  Humans typically produce approximately ~60 different protein variations of cytochrome p450, and I will be focusing on CYP3A4. 

Resouces for getting startedEdit


  1. Alessandra: Cytochrome p450: Introduction
  2. Alessandra: Cytochrome p450: Biological function
  3. Alessandra: Cytochrome p450: Biosynthesis
  4. Alessandra: Cytochrome p450: Gene sequence
  5. Alessandra: Cytochrome p450: Amino acid sequence and composition
  6. Alessandra: Cytochrome p450: Secondary and tertiary structure
  7. Alessandra: Cytochrome p450: Domains and structural motifs
  8. Alessandra: Cytochrome p450: Interactions with macromolecules and small molecules
  9. Alessandra: Cytochrome p450: Molecular biodiversity and evolution
  10. Alessandra: Cytochrome p450: Literature overview
  11. Alessandra: Cytochrome p450: Useful online resources
  12. Alessandra: Cytochrome p450: Pymol Images
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