Introduction to HIV-1 proteaseEdit

HIV-1 protease is a enzyme encoded by the RNA genome of the retroviral pathogen human immunodeficiency virus type-1. It catalyses several site-specific proteolytic reactions that are essential for the generation of HIV-1 proteins that function in viral replication and maturation. Inhibitors of HIV-1 protease serve to prevent viral replication and are used in the treatment of patients with HIV. Structural biologists played a critical role in the development of these protease inhibitors, since they were modeled using the three-dimensional structure of HIV-1 protease, determined by X-ray crystallographic methods.

6-HIV-1Protease-7hvp activesite

3D structure of HIV-1 protease homodimer. Left and center, complex with protease inhibitor. Right, no inhibitor.


Resources for getting startedEdit

Project pagesEdit

  1. John: HIV-1 Protease: Introduction (this page)
  2. John: HIV-1 Protease: Biological function
  3. John: HIV-1 Protease: Biosynthesis
  4. John: HIV-1 Protease: Gene sequence
  5. John: HIV-1 Protease: Amino acid sequence and composition
  6. John: HIV-1 Protease: Secondary and tertiary structure
  7. John: HIV-1 Protease: Domains and structural motifs
  8. John: HIV-1 Protease: Interactions with macromolecules and small molecules
  9. John: HIV-1 Protease: Molecular biodiversity and evolution
  10. John: HIV-1 Protease: Literature overview
  11. John: HIV-1 Protease: Useful online resources