Introduction to P-GlycoproteinEditP-glycoprotein (P-gp) is an ATP Binding Cassette (ABC)transporter that is found in Eukaryotic cells. The protein primarily functions as an ATP dependent efflux pump of foreign molecules. The protein is comprised of two homologous domains connected by a flexible linker chain.
Also known as MDR1 (Multi Drug Resistance family 1), P-gp can respond to a number of different foreign molecules. P-gp acts by first trapping a molecule into its clamping pocket and then flipping towards the outside of the membrane, releasing the held molecule. It is important to note that P-gp typically acts upon molecules that are non-polar and are 300-2000 kDa in size.
P-gp is a common molecule in epithelial cells that line vital organs such as the large and small intestines, the liver, the kidneys and even the brain. P-gp has a high relevance in cancer treatment, as many drugs administered during chemotherapy are effluxed by P-gp.
Some basic resources on these proteins.
- EBI multiple-database search results for "P-Glycoprotein"
- NCBI GQuery multiple-database search results for P-glycoprotein
- PDB Molecule of the month article on P-Glycoprotein
- Wikipedia Article on membrane bound transport proteins
- Wikipedia Article on P-Glycoprotein
- Yuzo: P-Glycoprotein: Introduction
- Yuzo: P-Glycoprotein: Biological function
- Yuzo: P-Glycoprotein: Biosynthesis
- Yuzo: P-Glycoprotein: Gene sequence
- Yuzo: P-Glycoprotein: Amino acid sequence and composition
- Yuzo: P-Glycoprotein: Secondary and Tertiary Structure
- Yuzo: P-Glycoprotein: Domains and structural motifs
- Yuzo: P-Glycoprotein: Interactions with macromolecules and small molecules
- Yuzo: P-Glycoprotein: Molecular biodiversity and evolutionYuzo: P-Glycoprotein: Pymol Images
- Yuzo: P-Glycoprotein: Pymol Images
- Yuzo: P-Glycoprotein: Literature overview
- Yuzo: P-Glycoprotein: Online resources