A collection of useful articles on P-Glycoprotein


  1. Aller, S.G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P.M., Trinh, Y.T., Zhang, Q., Urbatsch, I.L., et al. (2009). Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding. Science 323, 1718–1722.
  2. Ambudkar, S.V., Dey, S., Hrycyna, C.A., Ramachandra, M., Pastan, I., and Gottesman, M.M. (1999). Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu. Rev. Pharmacol. Toxicol. 39, 361–398.
  3. Ambudkar, S.V., Kimchi-Sarfaty, C., Sauna, Z.E., and Gottesman, M.M. (2003). P-glycoprotein: from genomics to mechanism. Oncogene 22, 7468–7485.
  4. Ford, J.M., and Hait, W.N. (1990). Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol Rev 42, 155–199.
  5. Fung, K.L., and Gottesman, M.M. (2009). A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function. Biochim Biophys Acta 1794, 860–871.
  6. Hrycyna, C.A., Ramachandra, M., Germann, U.A., Cheng, P.W., Pastan, I., and Gottesman, M.M. (1999). Both ATP sites of human P-glycoprotein are essential but not symmetric. Biochemistry 38, 13887–13899.
  7. Lam, F.C., Liu, R., Lu, P., Shapiro, A.B., Renoir, J.-M., Sharom, F.J., and Reiner, P.B. (2001). β-Amyloid efflux mediated by p-glycoprotein: β-Amyloid efflux mediated by an ABC transporter. Journal of Neurochemistry 76, 1121–1128.
  8. M M Cornwell, D.E.S. (1993). SP1 activates the MDR1 promoter through one of two distinct G-rich regions that modulate promoter activity. The Journal of Biological Chemistry 268, 19505–19511.
  9. Moitra, K., and Dean, M. (2011). Evolution of ABC transporters by gene duplication and their role in human disease. Biol. Chem. 392, 29–37.
  10. Scotto, K.W., and Egan, D.A. (1998). Transcriptional regulation of MDR genes. Cytotechnology 27, 257–269.